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Neurovirology
We aim at gaining a fundamental (mechanistic and structural) understanding of important stages of the life cycle of morbilliviruses ( e.g. canine distemper virus [CDV]). Morbilliviruses induce immune and respiratory pathologies. They can also affect the brain, with particularly high incidence upon CDV infection of dogs. In parallel of available vaccines, development of antivirals remains of major importance for disease management and represents a main mission of our lab. We are focusing on host- and virus-directed antiviral design in the format of small molecule compounds and multivalent synthetic single chain antibodies.
Fundings
Highlights
Melanie Scherer, Nadia Djabeur, Oliver Siering, Jean-Marc Jeckelmann, Marianne Wyss, Marina Cresci, Morgane Di Palma Subran, Rainer Riedl, Patrick Chames, Christian K Pfaller, Bevan Sawatsky , Dimitrios Fotiadis, Philippe Plattet
https://pubmed.ncbi.nlm.nih.gov/41501035/
Nanobody-based canine PD-L1-targeting immune checkpoint inhibitors for cancer therapy in dogs Morgane Di Palma Subran, Marianne Wyss, Betül Taskoparan, Mathischan Maheswaran, Johannes Vom Berg, Philippe Plattet , Patrick Chames
Mol Ther Oncol. 2025 Sep 8;33(3):201036. DOI: 10.1016/j.omton.2025.201036
Structure and supramolecular organization of the canine distemper virus attachment glycoprotein. Kalbermatter D, Jeckelmann JM, Wyss M, Shrestha N, Pliatsika D, Riedl R, Lemmin T, Plattet P, Fotiadis D.
Proc Natl Acad Sci U S A. 2023 Feb 7;120(6):e2208866120.
doi: 10.1073/pnas.2208866120.
LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus. Gradauskaite V, Inglebert M, Doench J, Scherer M, Dettwiler M, Wyss M, Shrestha N, Rottenberg S, Plattet P.
mBio. 2023 Jan 16:e0311422.
doi: 10.1128/mbio.03114-22.
Oligomerization and Cell Egress Controlled by Two Microdomains of Canine Distemper Virus Matrix Protein. Gast M, Kadzioch NP, Milius D, Origgi F, Plattet P. mSphere. 2021 Apr 14;6(2):e01024-20.
doi: 10.1128/mSphere.01024-20.
Cryo-EM structure of the prefusion state of canine distemper virus fusion protein ectodomain. Kalbermatter D, Shrestha N, Gall FM, Wyss M, Riedl R, Plattet P, Fotiadis D. J Struct Biol X. 2020 Feb 29;4:100021.
doi: 10.1016/j.yjsbx.2020.100021. eCollection 2020.
A list of all publications can be found here.